Neuropelveology, the integration of neuroscience with pelvic surgery, is transforming the management of chronic pelvic pain, particularly in cases of deep infiltrating endometriosis (DIE). Endometriosis can invade critical nerve structures such as the superior hypogastric plexus, sciatic nerve, and sacral nerves, leading to complex neuropathic pain that is often resistant to traditional treatments. This article …
Neuropelveology, the integration of neuroscience with pelvic surgery, is transforming the management of chronic pelvic pain, particularly in cases of deep infiltrating endometriosis (DIE). Endometriosis can invade critical nerve structures such as the superior hypogastric plexus, sciatic nerve, and sacral nerves, leading to complex neuropathic pain that is often resistant to traditional treatments. This article highlights the latest diagnostic and surgical advances aimed at preserving nerve function in endometriosis surgery.
Diagnostic Advances in Neuropathic Endometriosis
Diagnosing nerve involvement in endometriosis requires advanced imaging and clinical techniques. Pelvic magnetic resonance imaging (MRI) with neuroanatomical mapping has become a cornerstone for detecting nerve infiltration. While computed tomography (CT) and transvaginal ultrasound can assist, they are less accurate in evaluating nerve involvement.
In advanced cases, electromyography can assess neuromuscular impairment. During surgery, intraoperative nerve mapping with electrical stimulation is used to identify and protect critical nerves, allowing precise excision of endometriotic lesions with minimal risk of nerve damage.
Neuroanatomical Mapping and Advanced Laparoscopic Surgery
Neuroanatomical mapping is essential for planning nerve-sparing surgery. Using intraoperative electrical stimulation, surgeons can visualize and track the course of pelvic nerves, which may be displaced or infiltrated by endometriotic tissue. Functional MRI before surgery further refines the surgical plan, helping to achieve complete excision while minimizing neurological complications.
These technologies enable surgeons to perform complex procedures in a single surgery, reducing the need for repeated interventions and improving long-term outcomes.
Multidisciplinary Approach to Neuropathic Pain Management
Managing neuropathic pain in endometriosis requires a comprehensive, multidisciplinary strategy. Surgical intervention is often complemented by pharmacological therapies, including:
- Tricyclic antidepressants
- Selective serotonin reuptake inhibitors (SSRIs)
- Anticonvulsants like gabapentin and pregabalin
These medications target nerve activity to relieve chronic pain. For patients with persistent symptoms after surgery, neuromodulation techniques such as sacral nerve stimulation or spinal cord stimulation offer additional pain relief options.
Impact on Quality of Life and Surgical Outcomes
Advances in neuropelveology and nerve-sparing techniques have dramatically improved patient outcomes. Patients experience:
- Significant reductions in chronic pelvic pain
- Improvements in mobility and sexual function
- Enhanced overall quality of life
Studies demonstrate that combining nerve-sparing surgery with pharmacological and neuromodulation therapies results in better long-term outcomes and reduced recurrence rates compared to traditional surgical approaches without nerve mapping.
Neuropelveology has ushered in a paradigm shift in the surgical management of deep infiltrating endometriosis involving the nerves. Integrating advanced diagnostics, nerve preservation techniques, and multidisciplinary pain management leads to better surgical outcomes, reduced chronic pain, and improved patient quality of life.

At EndoGlobal Group, we are committed to applying these innovations to deliver state-of-the-art care for women suffering from this complex condition.